We have demonstrated tissue engineering approaches in our previous works to develop tissue clearing and tissue expansion technologies.
ELAST (Entangled Link-Augmented Stretchable Tissue-hydrogel) Technology
Ku et al. (2020) Nature Methods
MAP (Magnified Analysis of Proteome) Technology
Ku et al. (2016) Nature Biotechnology
Method of the Year 2016 in Nature Methods
25 Landmark papers in Nature Biotechnology
Park et al. (2021) Science Advances
This technology physically expands intact tissues and organs, while preserving their biomolecular content, such as proteins. The scenes of biological architecture in expanded tissues always look several times larger, enabling 3D super-resolution imaging at the tissue level.