Current research themes
We are developing novel engineering concepts that bypass the fundamental limitations in current bio-imaging to draw complete scenes of complex biological events.
Connectomics
The brain functions as networks of neurons. However, the intricate wiring diagram at the single-neuron level has been scarcely revealed. Drawing a complete map of this wiring (“connectome”) remains a significant challenge in neuroscience and bio-imaging. We recreate the brain in unique forms that unveil its extensive networks. Our ultimate goal is to decipher the mathematical rules governing how neural networks construct an entire brain. Our challenge is supported by the Suh Kyungbae Foundation.
Spatial transcriptomics
The trend in current biology has rapidly shifted towards single-cell transcriptomics, and the field is increasingly demanding transcriptomes contained within images—referred to as “spatial transcriptomics”. We are exploring creative ideas based on material engineering to develop efficient imaging tools that can provide more comprehensive transcriptomic information within a spatial context.
Image from Nature Methods 18(1). © Springer Nature.
Refer to an article in the issue: Method of the year: spatially resolved transcriptomics
Functional radiomics
Functional medical imaging techniques, such as positron emission tomography (PET), can measure and visualize functions in living bodies. Leveraging insights gained from our unique reverse tissue engineering approach, we transform existing functional medical imaging methods into novel and multi-functional radiomics technologies. Our goal is to create precision diagnostic tools for various diseases, including cancer and Alzheimer’s disease.